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Libra can make the two have different speeds.Both Jacob and Esau's speed will always be the same, and both will get changes to the speed stat.It is possible to only move Jacob when you hold the drop trinket and pill button (CTRL on PC/Right Trigger on default controller layout.).The card Suicide King is hard-coded not to appear while playing this character. Because cards, runes, and pills are used the moment they are picked up, the player cannot hold onto these for future use.Key and Knife pieces are not shared between Jacob and Esau, so if the player intends to fight Mega Satan or enter the Corpse, you must pick up all the pieces with only one of the two brothers.
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For example, if Jacob and Esau have 27 coins and then purchase 2 items that are at full price (30 coins), their coins will turn to -3, then increase to 3. Doing so will make Jacob and Esau's coins negative, but since the game cannot process having negative coins, they will become positive.
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Jacob and Esau are unlockable characters added in Antibirth.